What the evidence actually says

Peptide evidence

• BPC-157: what the FDA actually said, and what the trials show
  BPC-157 has no completed clinical trial in PubMed and the FDA put it in the category it reserves for safety concerns. Here is the record.
• IV glutathione: the FDA is investigating, and dermatology already ruled
  At least 30 patients had reactions to compounded IV glutathione in 2026, and a 2025 systematic review calls the IV route contraindicated.
• NAD+ drips: one randomized trial, and it wasn't about energy
  One randomized trial of intravenous NAD+ exists and it studied heart failure. The oral precursors have 24. What that gap means for buyers.
• Sermorelin: the peptide that used to be an approved drug
  Sermorelin was an approved drug until its maker pulled it. Nineteen randomized trials exist and none since 2005. What that means for buyers.

Buyer guide

• Compounded versus brand GLP-1s, without the marketing
  Compounded semaglutide is not a generic and not FDA-reviewed. Here are the rules that let it exist, and the ones it keeps breaking.
• How a telehealth prescription actually happens
  A questionnaire, a clinician you may never speak to, and a pharmacy nobody named. What each step in a telehealth intake really is.
• What “starting at” is really buying you
  The headline price in weight-loss telehealth is usually a prepaid year divided by twelve. Here is the arithmetic, measured across our own roster.

Reference

• Every peptide on a telehealth menu, and where the FDA actually put it
  Every peptide sold by telehealth companies, with its FDA compounding placement, approval status and randomized trial count, sourced cell by cell.

How these are put together

Citations are fetched, not remembered. A PubMed count is run through the E-utilities interface and printed with the exact query beside it, because a filter that silently matches nothing returns zero for every term and looks identical to a real absence. So every zero on these pages carries a positive control — a term we know is well studied, run through the identical filter in the same session — and the control’s count is printed next to the zero.

Regulatory documents are quoted from the version we read, with the date printed on the document rather than the date in its address. A live link can serve an old document, and an official link is not by itself verification.

None of this is how we judge a company. That is a separate standard, set out in how we grade, and it rests on prices sourced under how we verify prices. The companies themselves are in the graded roster.