NAD+ injections at home: cost and evidence

What this comes down to

• No drug containing NAD+ as its active ingredient has FDA approval. An at-home NAD+ injection is a compounded preparation, and the FDA does not check compounded drugs for safety, effectiveness or quality before they are sold.
• We found no published clinical trial of NAD+ injected under the skin. Two human studies of NAD+ itself gave it through an IV: an 11-man pilot that tracked blood levels, and a 180-patient heart-failure trial that used 10 mg a day for a week.
• Price: $93 to $249 a month for an NAD+ injection at the ten companies below. Several advertise a lower first month or a long-plan rate, so check what month two costs.

Is there an FDA-approved NAD+ injection?

No. No approved drug in the FDA's database lists nicotinamide adenine dinucleotide, NAD+, as its active ingredient. What a telehealth company ships is compounded: mixed by a pharmacy for a prescription, outside the approval process. The FDA says plainly that compounded drugs are not FDA-approved, which means it does not verify their safety, effectiveness or quality before they are marketed^[1]. How to check the pharmacy behind a compounded drug is the step that matters most here.

The search behind that answer. A Drugs@FDA search finds 0 results; the same search for tesamorelin through the identical field finds 1.

What did the NAD+ trials actually test?

Not at-home shots. Two human studies of NAD+ itself show what has been tested, and both gave it through an IV. The first, a 2019 pilot, infused 750 mg over six hours into 8 healthy men, with 3 more given saline, and tracked what happened to NAD+ in their blood and urine. It measured where the NAD+ went, not whether anyone felt or functioned better, and two of its authors were affiliated with an NAD+ research company and a clinic that offers NAD+ infusions^[2].

The second, published in early 2026, randomized 180 adults with heart failure from ischemic heart disease to IV NAD+ at 10 mg a day or a placebo for seven days, on top of their usual treatment. Heart pumping function at one month was a little better in the NAD+ group, 45.4% against 42.4%, and the six-month rate of serious heart events was 14.6% against 24.7%, a difference the trial itself did not find statistically significant^[3]. It was one hospital, in sick patients, at a dose far below the 750 mg the pilot described as a common clinic regimen^[2]. NAD+ IV therapy goes through the heart-failure trial and the oral precursors in more depth.

Trials of NAD+ given under the skin. A PubMed search finds 0 results; the same search for semaglutide in the title finds 132.

Most of the solid human work has used oral precursors, the building blocks the body turns into NAD+. Nicotinamide riboside taken by mouth raised blood NAD+ in healthy middle-aged and older adults and was well tolerated^[4]. Raising a blood level is a lab result, though; it does not by itself show that anyone gains energy, focus or a slower aging process.

How much do NAD+ injections cost a month?

At the ten telehealth companies below, an NAD+ injection costs $93 to $249 a month at the regular monthly price each one publishes, and at least half of them charge $155 or less. We have read NAD+ injection prices at 60 companies in all; each review has the full price list and what the plan includes.

NAD+ injections at telehealth companies we review, as each lists them (read September 2026 to October 2026)

Four of them also print a lower figure: System Labs ($89), Enhance MD ($169), Luvo Health ($99.50), and Wellorithm ($150). Those are first-month prices or the monthly rate of a longer prepaid plan, not what a single month costs once the offer ends. How starting-at prices work explains the pattern. Read the review before you buy: CoreAge Rx, DudeMeds, Live Vital, System Labs, MyDrHank, Enhance MD, Luvo Health, Wellorithm, RxSpan MD, and Sprout Health.

What side effects have been reported?

For NAD+ injected under the skin, there is no published rate to quote, because no trial has measured it. In the IV pilot, the researchers observed no adverse events during the six-hour infusion, and blood tests of liver function did not worsen^[2]. That was 8 men, once, at a slow drip; it says little about a shot repeated at home for months. Ask the prescriber what reactions to expect, what dose you will be sent, and what to do if a reaction happens.

What should you check before buying NAD+ injections?

• Which pharmacy compounds it, and whether it is licensed in your state. Checking a compounding pharmacy walks through the lookups.
• What one month costs after any first-month offer, and whether the advertised price needs a three-, six- or twelve-month prepayment. Refunds and cancellation covers getting out of a plan.
• What testing the pharmacy does on each lot. Purity and testing for injectables explains what a certificate of analysis should show.

Questions people actually ask