Nucific review
- Grade
- CCaveat
- Month to month
- Not published
- Month two
- +$68 a month
- over the advertised price
- FDA warning letter
- None found
- checked
Graded on whether a price is published, checkable, and still true at month two — how we grade · how we verify prices
Nucific charges $185 a month for compounded semaglutide and $220 for tirzepatide, month to month. The $117 and $139 on its homepage are yearly plans paid up front.
The headline needs a year paid up front ($1,404). Month to month costs $185, and the signup starts you on a 3-month plan at $169.
- Advertised $117, actually $185
- No month-to-month price published
- States not published
The verdict
The all-in price covers the drug, labs and clinician visits, and four pharmacies are named. But the homepage leads with the yearly rate without saying so, and the month-to-month price shows only at the end of a long signup.
Quick facts
Key facts
- Semaglutide, month to month
- $185 a month, drug, labs and visits included
- Tirzepatide, month to month
- $220 a month
- Homepage headline
- $117 semaglutide, $139 tirzepatide: the yearly plan, unlabeled
- Plan the signup picks first
- 3 months, $507 for semaglutide
- Where the monthly price appears
- Only at the end of a 30-screen signup
- Pharmacies named
- Four, with addresses, in the terms
- Refunds
- None once a billing cycle starts, unless a clinician turns you down first
- States
- All 50 and DC, per the terms
Pros and cons
What we like
- One price covers the medication, required lab work and clinician visits, with no membership fee.
- Month-to-month plans exist for both compounded drugs, at $185 and $220.
- The terms name four partner pharmacies with addresses.
- Clinical care comes from OpenLoop Health, a telehealth clinician network named in the terms.
- HSA and FSA eligible, with free shipping.
- The GLP-1 terms were updated in June 2026 and spell out cancellation timing.
What could be better
- The homepage's $117 and $139 are yearly prepaid rates, shown as "as low as" with no plan named.
- The month-to-month price appears only at the end of a 30-screen signup that asks for your email, phone and address first.
- The plan screen opens on a 3-month plan, not the monthly one.
- No refund once a billing cycle has begun, including if you cancel mid-cycle.
- The 90-day money-back guarantee covers supplements only, not GLP-1 plans.
- The homepage calls Dr. Amy Lee the founder, while the about page says she partners with Nucific.
What it is
Nucific is a supplement brand, known for its Bio-X4 digestive supplement, that now sells GLP-1 weight-loss care online. It offers compounded semaglutide and tirzepatide, lower-dose "microdose" versions of both, brand-name Ozempic and Zepbound, and NAD+, sermorelin and B12 injections. The company is Pacific Health Supplements, LLC in Westlake Village, California.
Nucific does not practice medicine itself. Clinicians in the OpenLoop Health network review your answers and prescribe, and the terms name four partner pharmacies with their addresses: RedRock Pharmacy in Utah, Health Warehouse in Kentucky, Precision Medicine in New York and Triad Rx in Alabama. The homepage calls Dr. Amy Lee, an obesity-medicine physician, Nucific's founder; its about page says she partners with the company.
Every price we found at Nucific
| Plan | Advertised | What you actually pay | The gap |
|---|---|---|---|
| Compounded semaglutide, monthlyBilled monthly. Drug, labs and visits included. | not published | $185 | not comparable |
| Compounded semaglutide, 3-month plan$507 billed every 3 months. Selected first on the plan screen. | $185 | $169 | |
| Compounded semaglutide, 6-month plan$870 billed every 6 months. | not published | $145 | not comparable |
| Compounded semaglutide, yearly plan$1,404 billed yearly. The homepage's starting price. | not published | $117 | not comparable |
| Compounded tirzepatide, monthlyBilled monthly. Drug, labs and visits included. | not published | $220 | not comparable |
| Compounded tirzepatide, 3-month plan$597 billed every 3 months. Selected first on the plan screen. | $220 | $199 | |
| Compounded tirzepatide, 6-month plan$1,020 billed every 6 months. | not published | $170 | not comparable |
| Compounded tirzepatide, yearly plan$1,668 billed yearly. The homepage's starting price. | not published | $139 | not comparable |
| Ozempic (brand)Billed monthly. | not published | $1,498 | not comparable |
| Zepbound (brand)Billed monthly. | not published | $1,828 | not comparable |
What it actually costs at Nucific
Month to month: $185 for semaglutide and $220 for tirzepatide, with the drug, labs and visits included. The homepage's $117 and $139 are the yearly plan.
The homepage says "Try GLP weight loss from $117/month" and lists semaglutide "as low as $117/month" and tirzepatide "as low as $139/month", with no plan named. We went through the signup to the price screen without paying. Those figures are the yearly plan, billed $1,404 and $1,668 up front. The same screen lists a 6-month plan at $145 and $170 a month, a 3-month plan at $169 and $199, and month to month at $185 and $220. That is a textbook starting-at price: the headline is the longest commitment.
Getting there takes about 30 screens: goals, height and weight, health history, medications, blood pressure, date of birth, then your email, phone and shipping address before any price appears. The plan screen opens with the 3-month plan selected, $507 billed every three months for semaglutide, and the monthly plan sits underneath under "Alternative Plans". Brand-name Ozempic is $1,498 a month and Zepbound $1,828.
The price covers the medication, required lab work and clinician visits, with no membership fee, free shipping, and HSA or FSA eligibility. Refunds are narrow: a full refund only if a clinician turns you down before treatment starts, and nothing if you cancel mid-cycle. Cancel at least 72 hours before the next billing date or that charge goes through. The 90-day money-back guarantee Nucific advertises covers its supplements, not GLP-1 plans. Our guide to GLP-1 refunds and cancellation explains why that matters on a prepaid plan.
Who it's wrong for
- Anyone budgeting off the homepage. The $117 semaglutide figure needs a year paid up front; month to month is $185.
- Anyone who wants a price before giving their email, phone and address. Nucific asks for all three first.
- Anyone who might stop partway through a prepaid plan. Fees are not refunded once a billing cycle starts.
- Anyone counting on Nucific's 90-day money-back guarantee. It applies to supplements only.
How Nucific works
A long online quiz
Goals, height and weight, health history, current medications, blood pressure and heart rate, then your date of birth, email, phone, state and shipping address.
Pick a drug and a plan
Compounded semaglutide or tirzepatide, or brand-name Ozempic or Zepbound. The 3-month plan is selected first; monthly, 6-month and yearly plans sit under it.
Pay when you submit
The terms say you are charged for the first billing cycle when your answers go to a clinician, with a full refund if you are turned down.
A clinician reviews it
A clinician in the OpenLoop Health network decides whether to prescribe; same-day approval is possible.
A pharmacy ships it
One of the named partner pharmacies ships the medication to your door, with free shipping.
Medications available
- Compounded semaglutideCompounded$185 a month
$117 a month on the yearly plan.
- Compounded tirzepatideCompounded$220 a month
$139 a month on the yearly plan.
- OzempicBrand$1,498 a month
- ZepboundBrand$1,828 a month
- Microdose semaglutide and tirzepatideCompounded
Lower-dose versions listed on the homepage with an "as low as" figure only.
- NAD+ and sermorelinCompounded
Listed on the homepage with an "as low as" monthly figure; we did not take that signup to its price screen.
Is Nucific legit?
Nucific is operated by Pacific Health Supplements, LLC (Nucific), 30700 Russell Ranch Road, Westlake Village, CA 91362, according to its website terms and conditions.
No FDA warning letters found — checked
Pharmacy, prescribers and safety checks
- Legal entityPacific Health Supplements, LLC, doing business as Nucific
- AddressWestlake Village, California
- CliniciansOpenLoop Health and its network of U.S.-licensed clinicians
- Pharmacies namedRedRock Pharmacy, Health Warehouse, Precision Medicine and Triad Rx
- States servedAll 50 states and DC, per the terms, with some services not available everywhere
- Drug formCompounded semaglutide and tirzepatide; brand-name Ozempic and Zepbound
- Governing lawCalifornia, with arbitration in Los Angeles
- GLP-1 terms last updatedJune 2026
Common questions
How much does Nucific cost per month?
Month to month, compounded semaglutide is $185 and tirzepatide is $220, with the drug, required labs and clinician visits included. Longer plans lower the monthly rate: $169 and $199 on 3 months, $145 and $170 on 6 months, $117 and $139 on a year paid up front.
Is the Nucific $117 price real?
Yes, but only on the yearly plan, billed $1,404 at once for semaglutide. The homepage does not say so; month to month is $185.
Does Nucific sell Ozempic or Zepbound?
Yes, as brand-name options on its plan screen: Ozempic at $1,498 a month and Zepbound at $1,828, each billed monthly.
Can I get a refund from Nucific?
Only if a clinician turns you down before treatment begins, for a billing error, or where the law requires one. Canceling mid-cycle does not earn a refund, and you need to cancel at least 72 hours before the next billing date.
Who prescribes and fills Nucific medication?
Clinicians in the OpenLoop Health network prescribe, and the terms name four partner pharmacies: RedRock Pharmacy, Health Warehouse, Precision Medicine and Triad Rx.
Is Nucific legit?
Nucific is the brand of Pacific Health Supplements, LLC in Westlake Village, California, and we found no FDA warning letter addressed to it. The GLP-1 care itself comes from OpenLoop Health's clinicians.
Does Nucific's money-back guarantee cover GLP-1 plans?
No. The 90-day money-back guarantee on its returns page covers supplement products. GLP-1 plans follow separate terms with no refund once a billing cycle starts.
Why we gave Nucific a C
Read the full grading rationale
The homepage's $117 and $139 are yearly plans paid up front, shown as "as low as" with no plan named. The month-to-month prices, $185 for semaglutide and $220 for tirzepatide, appear only at the end of a 30-screen signup that opens on a 3-month plan. The price includes the drug, labs and visits, and four pharmacies are named. Fees are not refunded once a billing cycle starts.
Read the evidence
How we reviewed Nucific
We read Nucific's homepage, about and returns pages, both sets of terms, its privacy policy and its cancellation policy.
We went through its GLP-1 signup to the price screen without paying, and every plan price here is quoted from that screen.
Where each price comes from
- Cmqpec4ba3wb2s6017xdk08pn page
3 MONTH SUPPLY 3-month plan Save $48.00 $507.00 billed every 3 months $169.00 /monthly $185.00 Alternative Plans Select a plan that fits your goals. Monthly plan $185.00 billed monthly $185.00 /monthly 6 MONTH SUPPLY 6-month plan Save $240.00 $870.00 billed every 6 months $145.00 /monthly $185.00 ANNUAL PLAN Yearly plan Save $816.00 $1,404.00 billed yearly $117.00 /monthly $185.00
Alternatives to Nucific
| Provider | Grade | Cheapest price |
|---|---|---|
| Fridays | CCaveat | $117/mo |
| Blue Haven Rx | CCaveat | $119/mo |
| Independent Wellness | CCaveat | $99/mo |
| JYRA Health | BMinor gap | $99/mo |
| Sprout Health | BMinor gap | $99/mo |